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ripretinib

Pronunciation: rip RE ti nib

Brand: Qinlock

What is the most important information I should know about ripretinib?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What is ripretinib?

Ripretinib is used to treat tumors of the stomach and intestines.

Ripretinib is for use in adults who have already been treated with at least 3 other cancer medicines.

Ripretinib may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking ripretinib?

You may not be able to use ripretinib if you have untreated or uncontrolled hypertension (high blood pressure).

Tell your doctor if you have ever had:

  • high blood pressure;
  • heart problems; or
  • if you have recently had surgery or plan to have surgery.

Using ripretinib may increase your risk of developing skin cancer. Your skin may need to be checked while you are using this medicine. Ask your doctor about skin symptoms to watch for.

You may need to have a negative pregnancy test before starting this treatment.

Both men and women using this medicine should use effective birth control to prevent pregnancy. Ripretinib can harm an unborn baby if the mother or father is using this medicine.

Use effective birth control to prevent pregnancy while you are using this medicine and for at least 1 week after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using ripretinib.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because ripretinib can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

Ripretinib is not approved for use by anyone younger than 18 years old.

How should I take ripretinib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Swallow the tablet whole and do not crush, chew, or break it.

Take the medicine at the same time each day, with or without food.

If you vomit shortly after taking ripretinib, do not take another dose. Wait until your next scheduled dose time to take the medicine again.

Your blood pressure will need to be checked often. Your heart function may also need to be checked.

If you need surgery, tell your surgeon you currently use this medicine. You may need to stop for a short time.

Do not change your dose or stop taking ripretinib without your doctor's advice.

Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if you are more than 8 hours late for the dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking ripretinib?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of ripretinib?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe stomach pain, nausea, or vomiting;
  • severe headache, blurred vision, pounding in your neck or ears;
  • pain, blisters, bleeding, or severe rash in the palms of your hands or the soles of your feet;
  • heart problems --tiredness, feeling short of breath, swollen veins in the sides of your neck, swelling in your stomach or lower legs;
  • low red blood cells (anemia) --pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or
  • skin changes --a new wart, a skin sore or red bump that bleeds or does not heal, or any change in the size or color of a mole.

Common side effects may include:

  • nausea, vomiting, stomach pain, loss of appetite;
  • diarrhea, constipation;
  • tiredness;
  • muscle pain;
  • thinning hair, hair loss;
  • abnormal blood tests; or
  • severe rash on your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ripretinib?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your other medicines, especially blood pressure medicine.

Other drugs may affect ripretinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about ripretinib.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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